RenardV1, Main, Exploration, bibRecord, 000239

Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination

Identifieur interne : 000239 ( Main/Exploration ); précédent : 000238; suivant : 000240

Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination

Auteurs : Florence Cliquet [France] ; Emmanuelle Robardet [France] ; Evelyne Picard Meyer [France]

Source :

Antiviral research [ 0166-3542 ] ; 2013.

RBID : Pascal:14-0016840

Descripteurs français

Pascal (Inist)
- Génétique, Souche atténuée, Virus rage, Europe, Animal sauvage, Voie orale, Vaccination, Immunoprophylaxie, Rage, Vaccin, Prévention, Séquençage, Séquence nucléotide, Phylogenèse, Nucléotide, Mutation.
Wicri :
- topic : Génétique, Vaccination, Rage, Vaccin.

English descriptors

KwdEn :
- Attenuated strain, Europe, Genetics, Immunoprophylaxis, Mutation, Nucleotide, Nucleotide sequence, Oral administration, Phylogeny, Prevention, Rabies, Rabies virus, Sequencing, Vaccination, Vaccine, Wild animal.

Abstract

In Europe, the main reservoir and vector of rabies has been the red fox (Vulpes vulpes). Oral immunization of foxes with live vaccines, using attenuated rabies strains (SAD B19, SAD Bern), apathogenic mutants of an attenuated strain (SAG2) and the vaccinia-rabies glycoprotein recombinant virus vaccine (V-RG), has been shown to be the most effective method for the control and elimination of rabies. Among all vaccines currently used for wildlife oral vaccination, one vaccine (marketed as SAD Bern strain) has been widely used in Europe since 1992 with the distribution of 17 million of baits in 2011. Because of the potential environmental safety risk of a live virus which could revert to virulence, the full genome sequencing of this vaccine was undertaken and the sequence was characterized and compared with those of referenced rabies viruses. The vaccine showed higher similarity to the strains belonging to the SAD B19 vaccine virus strains than to the SAD Bern vaccines. This study is the first one reporting on virus strain identity changes in this attenuated vaccine.

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000004
to stream PascalFrancis, to step Curation: 000084
to stream PascalFrancis, to step Checkpoint: 000007
to stream Main, to step Merge: 000240
to stream Main, to step Curation: 000239

Le document en format XML

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<front><div type="abstract" xml:lang="en">In Europe, the main reservoir and vector of rabies has been the red fox (Vulpes vulpes). Oral immunization of foxes with live vaccines, using attenuated rabies strains (SAD B19, SAD Bern), apathogenic mutants of an attenuated strain (SAG2) and the vaccinia-rabies glycoprotein recombinant virus vaccine (V-RG), has been shown to be the most effective method for the control and elimination of rabies. Among all vaccines currently used for wildlife oral vaccination, one vaccine (marketed as SAD Bern strain) has been widely used in Europe since 1992 with the distribution of 17 million of baits in 2011. Because of the potential environmental safety risk of a live virus which could revert to virulence, the full genome sequencing of this vaccine was undertaken and the sequence was characterized and compared with those of referenced rabies viruses. The vaccine showed higher similarity to the strains belonging to the SAD B19 vaccine virus strains than to the SAD Bern vaccines. This study is the first one reporting on virus strain identity changes in this attenuated vaccine.</div>
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Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination

Genetic strain modification of a live rabies virus vaccine widely used in Europe for wildlife oral vaccination

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri